The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population

Background and aimsAt the same BMI, Asian populations develop cardiometabolic complications earlier than Western populations. We hypothesized that a different secretion of adipocyte-derived hormones leptin adiponectin plays role investigated associations two with metabolic syndrome (MetS) in an Indonesian Dutch population.Methods resultsWe performed cross-sectional analyses Netherlands Epidemiology Obesity Study (n = 6602) SUGAR Scientific Programme Indonesia–Netherlands 1461). examined sex-stratified MetS, using multivariate logistic regression including adjustment for total body fat. The mean (SD) (mcg/L) were 4.7 (6.0) men, 18.6 (12.0) women, 9.1 (7.7) 23.4 (17.4) women. (mg/L) 5.7 (5.4), 7.5 (7.1), 6.6 (3.3), 11.3 (4.9), respectively. Within BMI category, concentrations similar populations, whereas was lower population. Per SD leptin, adjusted prevalence odds ratios (ORs, 95%CI) MetS 0.9 (0.6–1.2) 1.1 (0.9–1.4) 2.2 (1.6–2.8) 1.2 (1.0–1.5) adiponectin, ORs (0.7–1.2), 0.8 (0.7–1.0), 0.6 (0.6–0.8), 0.4 (0.4–0.5), respectively.ConclusionsDespite levels, not related to population can explain their increased risk at BMI.